MCAM antibody (Melanoma Cell Adhesion Molecule) (AA 84-189)

Details for Product anti-MCAM Antibody No. ABIN1724898
Antigen
Epitope
AA 84-189
19
17
16
13
8
7
6
6
6
4
4
4
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
366
86
64
24
15
12
12
6
4
2
Host
Mouse
249
171
2
1
1
1
Clonality (Clone)
Monoclonal ()
Conjugate
This MCAM antibody is un-conjugated
31
29
21
8
7
6
5
5
5
5
5
4
4
4
4
4
4
4
4
4
4
4
4
4
2
2
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
236
189
171
114
94
76
43
29
16
14
13
9
6
4
2
2
2
1
1
Options
Immunogen Purified recombinant fragment of human MCAM (AA 84-189) expressed in E. Coli.
Clone 6C3F1
Isotype IgG1
Purification Purified
Antigen
Alternative Name MCAM (MCAM Antibody Abstract)
Background The protein encoded by this gene plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during , embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration ,
Molecular Weight 71.6 kDa
Gene ID 4162
HGNC 4162
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Melanoma Cell Adhesion Molecule (MCAM) (AA 84-189) antibody (ABIN1724898) Immunohistochemical analysis of paraffin-embedded kidney tissues using MCAM mouse mAb...
Image no. 2 for anti-Melanoma Cell Adhesion Molecule (MCAM) (AA 84-189) antibody (ABIN1724898) Immunohistochemical analysis of paraffin-embedded liver cancer tissues using MCAM mou...
Product cited in: Wang, Yan: "CD146, a multi-functional molecule beyond adhesion." in: Cancer letters, Vol. 330, Issue 2, pp. 150-62, 2013 (PubMed).

Jouve, Despoix, Espeli, Gauthier, Cypowyj, Fallague, Schiff, Dignat-George, Vély, Leroyer: "The involvement of CD146 and its novel ligand Galectin-1 in apoptotic regulation of endothelial cells." in: The Journal of biological chemistry, Vol. 288, Issue 4, pp. 2571-9, 2013 (PubMed).