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Raptor antibody (AA 874-1009)

RPTOR Reactivity: Human ELISA Host: Mouse Monoclonal 6G9C4 unconjugated
Catalog No. ABIN1724920
  • Target See all Raptor (RPTOR) Antibodies
    Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
    Binding Specificity
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 874-1009
    Reactivity
    • 43
    • 6
    • 3
    Human
    Host
    • 35
    • 8
    Mouse
    Clonality
    • 35
    • 8
    Monoclonal
    Conjugate
    • 23
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Raptor antibody is un-conjugated
    Application
    • 23
    • 15
    • 13
    • 7
    • 5
    • 4
    • 4
    • 3
    ELISA
    Purpose
    RPTOR Antibody
    Purification
    Purified antibody
    Immunogen
    Purified recombinant fragment of human RPTOR (AA: 874-1009) expressed in E. Coli.
    Clone
    6G9C4
    Isotype
    IgG1
  • Application Notes
    ELISA: 1/10000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified antibody in PBS with 0.05 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Vazquez-Martin, Cufí, Oliveras-Ferraros, Menendez: "Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)." in: Cell cycle (Georgetown, Tex.), Vol. 10, Issue 18, pp. 3140-52, (2011) (PubMed).

    Sun, Southard, Witonsky, Kittler, Di Rienzo: "Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations." in: PLoS genetics, Vol. 6, Issue 10, pp. e1001178, (2010) (PubMed).

  • Target
    Raptor (RPTOR) (Regulatory Associated Protein of mTOR, Complex 1 (RPTOR))
    Alternative Name
    RPTOR (RPTOR Products)
    Background

    Description: This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene.

    Aliases: KOG1, Mip1

    Molecular Weight
    149kDa
    Gene ID
    57521
    HGNC
    57521
    UniProt
    Q8N122
    Pathways
    PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development, Autophagy, BCR Signaling, Warburg Effect
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