Raptor antibody (Regulatory Associated Protein of MTOR, Complex 1) (AA 874-1009)

Details for Product anti-RPTOR Antibody No. ABIN1724920
Antigen
Epitope
AA 874-1009
7
7
5
4
3
3
2
1
1
1
1
1
1
1
Reactivity
Human
51
13
3
Host
Mouse
42
11
Clonality (Clone)
Monoclonal ()
Conjugate
This Raptor antibody is un-conjugated
4
3
3
2
2
2
1
1
1
1
1
1
Application
ELISA, Western Blotting (WB)
26
23
14
10
7
6
5
4
1
1
1
Options
Immunogen Purified recombinant fragment of human RPTOR (AA 874-1009) expressed in E. Coli.
Clone 6G9C4
Isotype IgG1
Purification Purified
Antigen
Alternative Name RPTOR (RPTOR Antibody Abstract)
Background This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. ,
Molecular Weight 149 kDa
Gene ID 57521
HGNC 57521
Pathways PI3K-Akt Signaling, RTK Signaling, AMPK Signaling, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Skeletal Muscle Fiber Development
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000
Restrictions For Research Use only
Format Liquid
Buffer PBS with 0.05 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Regulatory Associated Protein of MTOR, Complex 1 (RPTOR) (AA 874-1009) antibody (ABIN1724920) anti-Regulatory Associated Protein of MTOR, Complex 1 (RPTOR) (AA 874-1009) antibody (Image 1)
Image no. 2 for anti-Regulatory Associated Protein of MTOR, Complex 1 (RPTOR) (AA 874-1009) antibody (ABIN1724920) anti-Regulatory Associated Protein of MTOR, Complex 1 (RPTOR) (AA 874-1009) antibody (Image 2)
Image no. 3 for anti-Regulatory Associated Protein of MTOR, Complex 1 (RPTOR) (AA 874-1009) antibody (ABIN1724920) anti-Regulatory Associated Protein of MTOR, Complex 1 (RPTOR) (AA 874-1009) antibody (Image 3)
Product cited in: Vazquez-Martin, Cufí, Oliveras-Ferraros, Menendez: "Raptor, a positive regulatory subunit of mTOR complex 1, is a novel phosphoprotein of the rDNA transcription machinery in nucleoli and chromosomal nucleolus organizer regions (NORs)." in: Cell cycle (Georgetown, Tex.), Vol. 10, Issue 18, pp. 3140-52, 2011 (PubMed).

Sun, Southard, Witonsky, Kittler, Di Rienzo: "Allele-specific down-regulation of RPTOR expression induced by retinoids contributes to climate adaptations." in: PLoS genetics, Vol. 6, Issue 10, pp. e1001178, 2010 (PubMed).