CSF1R antibody (AA 344-497)

Catalog No. ABIN1724928

This anti-CSF1R antibody is a Mouse Monoclonal antibody detecting CSF1R in ELISA, IHC and FACS. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for CSF1R antibody (AA 344-497) (ABIN1724928)

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CSF1R antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: 6B9H2

Product Details anti-CSF1R Antibody

Binding Specificity: AA 344-497

Purpose: CSF1R Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human CSF1R (AA: 344-497) expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CSF1R antibody (ABIN1724928)

Morandi, Barbetti, Riverso, Dello Sbarba, Rovida: "The colony-stimulating factor-1 (CSF-1) receptor sustains ERK1/2 activation and proliferation in breast cancer cell lines." in: PLoS ONE, Vol. 6, Issue 11, pp. e27450, (2011) (PubMed).

Kitagawa, Gouda, Kirii, Sugiyama, Ishihama, Fujii, Narumi, Akita, Yokota: "Characterization of kinase inhibitors using different phosphorylation states of colony stimulating factor-1 receptor tyrosine kinase." in: Journal of biochemistry, Vol. 151, Issue 1, pp. 47-55, (2011) (PubMed).

Target Details for CSF1R

Target: CSF1R (Colony Stimulating Factor 1 Receptor (CSF1R))

Alternative Name: CSF1R

Background: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction.

Molecular Weight: 108 kDa

Gene ID: 1436

UniProt: P07333

Pathways: RTK Signaling, Inositol Metabolic Process, Cell-Cell Junction Organization