EIF2A antibody (AA 448-576)

Catalog No. ABIN1724939

There are 2+ publications for this product available. The Mouse Monoclonal anti-EIF2A antibody is suitable to detect EIF2A in samples from Human. It has been validated for WB, IHC, ELISA, FACS and ICC.

Quick Overview for EIF2A antibody (AA 448-576) (ABIN1724939)

Target: EIF2A (Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This EIF2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 3A7A8

Product Details anti-EIF2A Antibody

Binding Specificity: AA 448-576

Purpose: EIF2A Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human EIF2A (AA: 448-576) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-EIF2A antibody (ABIN1724939)

Yerlikaya, DoKudur: "Investigation of the eIF2alpha phosphorylation mechanism in response to proteasome inhibition in melanoma and breast cancer cells." in: Molekuliarnaia biologiia, Vol. 44, Issue 5, pp. 859-66, (2010) (PubMed).

Schewe, Aguirre-Ghiso: "Inhibition of eIF2alpha dephosphorylation maximizes bortezomib efficiency and eliminates quiescent multiple myeloma cells surviving proteasome inhibitor therapy." in: Cancer research, Vol. 69, Issue 4, pp. 1545-52, (2009) (PubMed).

Target Details for EIF2A

Target: EIF2A (Eukaryotic Translation Initiation Factor 2A, 65kDa (EIF2A))

Alternative Name: EIF2A

Background: EIF2A is a 65-kD protein that catalyzes the formation of puromycin-sensitive 80S preinitiation complexes

Molecular Weight: 65 kDa

Gene ID: 83939

UniProt: Q9BY44

Pathways: Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C, Methionine Biosynthetic Process, Ribosome Assembly