Metabotropic Glutamate Receptor 1 antibody (AA 1159-1171)

Catalog No. ABIN1736899

This Rabbit Polyclonal antibody specifically detects Metabotropic Glutamate Receptor 1 in WB and IHC. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Metabotropic Glutamate Receptor 1 antibody (AA 1159-1171) (ABIN1736899)

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Metabotropic Glutamate Receptor 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-Metabotropic Glutamate Receptor 1 Antibody

Binding Specificity: AA 1159-1171

Specificity: Reacts with GluR1 protein form human, mouse and rat

Purification: Antigen affinity purified

Immunogen: Synthetic peptide comprising residues 1159-1171 [SSVPSSPVSESVL] of the human GluR1 protein.

Isotype: IgG

Application Details

Application Notes:

Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only:
- IHC : 1/100 to 1/500 - WB : 1/500 to 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS, Sodium azide 0.02 %

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Short term storage at +4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 month from date of receipt.

Expiry Date: 6 months

Target Details for Metabotropic Glutamate Receptor 1

Target: Metabotropic Glutamate Receptor 1 (GRM1) (Glutamate Receptor, Metabotropic 1 (GRM1))

Alternative Name: Metabotropic Glutamate Receptor 1a (mGluR1)

Background: The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors.Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C.Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined.Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.mGluR1 has been reported in various regions of the brain and spinal cord.ESTs have been isolated from brain and eye libraries.Caution:GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).