Thyroglobulin antibody

Catalog No. ABIN180965

The Mouse Monoclonal anti-Thyroglobulin antibody is suitable to detect Thyroglobulin in samples from Human. It has been validated for EIA and ELISA (Capture).

Quick Overview for Thyroglobulin antibody (ABIN180965)

Target: Thyroglobulin (TG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Thyroglobulin antibody is un-conjugated

Application: Enzyme Immunoassay (EIA), ELISA (Capture)

Clone: BGN-6E10

Product Details anti-Thyroglobulin Antibody

Specificity: Reacts with different epitope to clone BGN/6D7 (BM733) and can be used as the coated antibody in 2 site assay with this clone.

Characteristics: Synonyms: Thyreoglobulin, TGN

Purification: Affinity Chromatography on Protein G.

Immunogen: Purified Native Human Thyreoglobulin.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Thyroglobulin

Target: Thyroglobulin (TG)

Background: Thyroglobulin is the glycoprotein precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is obtained from the thyroid gland and exhibits the general properties of the globulins. The human thyroglobulin (hTG) is a high molecular weight glycoprotein (605 kDa) found in the thyroid follicular cells. It plays a central role in the uptake, incorporation, and regulated biosynthesis of thyroid hormones, T4 and T3. Thyroid disorders are, in large part, due to autoimmune origin, and anti thyroglobulin autoantibodies were the first factor to be discovered. Anti hTG is found in all thyroid autoimmune diseases (Hashimoto's thyroiditis, Graves' diseases), with the highest level observed in Hashimoto's thyroiditis. Anti hTG is also characteristic of thyroid cancer, and its determination can be used for the follow up of cancer patients.Synonyms: TGN, Thyreoglobulin

Gene ID: 7038

UniProt: P01266

Pathways: Thyroid Hormone Synthesis