Interleukin 17a antibody

Catalog No. ABIN181034

The Rat Monoclonal anti-Interleukin 17a antibody is suitable to detect Interleukin 17a in samples from Mouse. It has been validated for WB, FACS, EIA and IHC (p).

Quick Overview for Interleukin 17a antibody (ABIN181034)

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Interleukin 17a antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TC11-18H10

Product Details anti-Interleukin 17a Antibody

Specificity: This antibody recognizes Mouse Interleukin 17, a 32 kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belong to the IL-17 family

Characteristics: Synonyms: IL-17A, IL17, IL-17, CTLA8, CTLA-8, Cytotoxic T-lymphocyte-associated antigen 8

Purification: Purified

Isotype: IgG1

Application Details

Application Notes: Western Blot. Flow Cytometry. ELISA: Can be used in a sandwich ELISA with ABIN181031 as a detection antibody.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.5 mg/mL

Buffer: Borate buffered saline with no preservative or stabilizer

Preservative: Without preservative

Storage: -20 °C

Storage Comment: Store the antibody in aliquots at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Expiry Date: 12 months

Target Details for Interleukin 17a

Target: Interleukin 17a (IL17A) (Interleukin 17A (IL17A))

Alternative Name: Interleukin-17A (IL17A)

Background: IL17, also known as CTLA8, is a T cell derived hematopoietic cytokine. It was originally cloned from a T cell hybridoma produced by fusion of a mouse cytotoxic T cell clone and a rat T lymphoma. IL17 exhibits multiple biological activities on a variety of cells including: the induction of IL6, IL8 and GCSF production in fibroblasts, the enhancement of surface expression of ICAM 1 in fibroblasts, activation of NF kappaB and costimulation of T cell proliferation. IL17 is an approximately 16 kDa polypeptide of 136 amino acids. The precursor form of IL17 consists of 155 amino acids. To generate the mature IL17 (136 amino acids), the precursor cleaves a 19 amino acid signal peptide. Human IL17 shows approximately 62.5 % amino acid homology to mouse IL17 and 58 % amino acid homology to rat IL17.Synonyms: CTLA-8, CTLA8, Cytotoxic T-lymphocyte-associated antigen 8, IL-17, IL-17A, IL17

Gene ID: 16171

UniProt: Q62386