SIGLEC7 antibody

Catalog No. ABIN1819168

This Mouse Monoclonal antibody specifically detects SIGLEC7 in WB, ELISA, FACS, IP, Func and DNA Mic. It exhibits reactivity toward Human, Rhesus Monkey and Monkey.

Quick Overview for SIGLEC7 antibody (ABIN1819168)

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Reactivity: Human, Rhesus Monkey, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This SIGLEC7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunoprecipitation (IP), Functional Studies (Func), DNA Microscopy (DNA Mic)

Clone: S7-7

Product Details anti-SIGLEC7 Antibody

Specificity: Recognizes human Sialic acid-binding Ig-like lectin 7, otherwise known as CD328, a putative adhesion molecule and member of the Ig superfamily, predominantly expressed by both resting and activated natural killer (NK) cells, and also at lower levels by monocytes, granulocytes, monocyte-derived macrophages and dendritic cells, and a small population of CD8+ memory T cells. Classified as a CD33-related Siglec, Siglec-7 preferentially binds to glycoconjugates containing alpha-2,3- or alpha-2,6-linked sialic acid, and acts as a novel inhibitory receptor for NK cells, mediating the inhibition of NK cell cytotoxicity, and implicated in the regulation of NK cell and T cell activation, and hematopoiesis. Clone S7.7 is a blocking antibody see for details, and has been shown to recognize Siglec-7 in Rhesus monkey see for details.

Purification: Protein G purified

Endotoxin Level: Low Endotoxin

Immunogen: Siglec-7 3T3 transfected cells.

Type of Immunogen: Cells

Isotype: IgG1

Application Details

Application Notes: Approved: ELISA, Flo, Func, IP, WB

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for SIGLEC7

Target: SIGLEC7 (Sialic Acid Binding Ig-Like Lectin 7 (SIGLEC7))

Alternative Name: SIGLEC7 / CD328

Background: Name/Gene ID: SIGLEC7
Family: Immunoglobulin

Synonyms: SIGLEC7, AIRM-1, AIRM1, CD328 antigen, CDw328, CD328, D-siglec, QA79, SIGLEC-7, QA79 membrane protein

Gene ID: 27036