IL23R antibody (AA 59-87)

Catalog No. ABIN1819424

The Goat Polyclonal anti-IL23R antibody has been validated for WB, IHC and IHC (p). It is suitable to detect IL23R in samples from Human and Mouse.

Quick Overview for IL23R antibody (AA 59-87) (ABIN1819424)

Target: IL23R (Interleukin 23 Receptor (IL23R))

Reactivity: Human, Mouse

Host: Goat

Clonality: Polyclonal

Conjugate: This IL23R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IL23R Antibody

Binding Specificity: AA 59-87

Specificity: Recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kD single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two domains. Multiple potential isoforms formed by alternative splicing are described. Recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4, the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signalling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 and susceptibility to the ulcerative and inflammatory psoriasis. Is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues.

Purification: Affinity purified

Immunogen: Synthetic peptide CQPRKLHFYKNGIKERFQITRINKTTARL corresponding to amino acids 59-87 within the N-terminal region of human IL-23 receptor. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan (100%), Marmoset, Dog (97%), Gibbon, Monkey, Panda (93%), Ferret, Bovine, Cat, Horse, Pig (90%).

Type of Immunogen: Synthetic peptide

Isotype: IgG

Application Details

Application Notes: Approved: IHC, IHC-P (1:125), WB (1:500)

Usage: Use in IHC requires heat treatment prior to staining.

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS, 0.1 % sodium azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: 4°C or -20°C, Avoid freeze-thaw cycles.

Target Details for IL23R

Target: IL23R (Interleukin 23 Receptor (IL23R))

Alternative Name: IL23R

Background: Name/Gene ID: IL23R
Family: Interleukin

Synonyms: IL23R, IL-23 receptor, Interleukin 23 receptor, IBD17, IL-23R, Interleukin-23 receptor

Gene ID: 149233

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation