DC-SIGN/CD209 antibody

Catalog No. ABIN181974

The Mouse Monoclonal anti-DC-SIGN/CD209 antibody (Clone MR-1) (ABIN181974) specifically detects DC-SIGN/CD209 in FACS, IF and Func. The antibody is reactive with Human samples.

Quick Overview for DC-SIGN/CD209 antibody (ABIN181974)

Target: DC-SIGN/CD209 (CD209) (CD209)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DC-SIGN/CD209 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunofluorescence (IF), Functional Studies (Func)

Clone: MR-1

Product Details anti-DC-SIGN/CD209 Antibody

Specificity: This antibodies recognises human DC-specific ICAM-3 grabbing nonintegrin (DC-SIGN), a 45 kDa C-type lectin that binds ICAM-3 also known as CD209.

Purification: Protein G affinity chromatography

Endotoxin Level: Low Endotoxin

Immunogen: Immature myeloid monocyte-derived dendritic cells (MDDCs)

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: Use 10 μL to label 10^6 cells in 100 μL. Immunofluorescence. Functional assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, without preservatives or stbilizers

Preservative: Without preservative

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the lyophilized antibody at -20 °C. Following reconstitution it is stable for two weeks at 2-8 °C. Frozen aliquots are stable for 6 months when stored at -20 °C.

Expiry Date: 6 months

Target Details for DC-SIGN/CD209

Target: DC-SIGN/CD209 (CD209) (CD209)

Alternative Name: CD209 / DC-SIGN

Background: CD209 is primarily expressed on a population of immature dendritic cells in peripheral tissues and on immature myeloid monocyte-derived DC's in vitro. CD209 is involved in dendritic cell (DC) migration and the initial interaction between DC's and naive T lymphocytes. CD209 also binds HIV-1 gp120 and plays a key role in the dissemination of HIV-1 by DC's. Clone MR-1 is reported to partially block the functional activity of DC-SIGN(2).Synonyms: C-type lectin domain family 4 member L, CLEC4L, DC-SIGN1, DCSIGN, DCSIGN1, Dendritic Cell Marker, Dendritic cell-specific ICAM-3-grabbing non-integrin 1

Gene ID: 9606

UniProt: Q9NNX6