TREM2 antibody

Catalog No. ABIN1820125

Product Details anti-TREM2 Antibody

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This TREM2 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func)

Specificity: Recognizes Triggering receptor expressed on myeloid cells 2 (TREM-2), an activating receptor of the Ig superfamily. TREM-2 forms a receptor signalling complex with DAP12 to trigger the activation of the immune response in macrophages and dendritic cells. It may be involved in chronic inflammation and may promote the production of constitutive rather than inflammatory chemokines and cytokines. TREM-2 may also have a functional role in osteoclast formation. Stimulation of TREM-2 with clone 78.18 enhances multinucleated osteoclast formation in vitro. Clone 78.18 may also be used to block TREM-2 on pre-osteoclasts to inhibit the formation of multinuclear osteoclasts and to inhibit bone resorption by mature osteoclasts.

Purification: Protein G purified

Endotoxin Level: Low Endotoxin

Immunogen: Mouse TREM-2 Fc fusion protein.

Type of Immunogen: Fusion protein

Clone: 78-18

Isotype: IgG1

Application Details

Application Notes: Approved: Flo (1:25 - 1:200), Func

Usage: The applications listed have been tested for the unmodified form of this product. Other forms have not been tested.

Comment:

Target Species of Antibody: Mouse

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: PBS

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for TREM2

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Alternative Name: TREM2 / TREM-2 (TREM2 Products)

Background: Name/Gene ID: TREM2

Synonyms: TREM2, Trem2b, TREM-2, Trem2a, Trem2c

Gene ID: 54209