Caspase 7 antibody (N-Term)

Catalog No. ABIN187518

The Mouse Monoclonal anti-Caspase 7 antibody (Clone MCH3-14) (ABIN187518) specifically detects Caspase 7 in WB. The antibody is reactive with Human samples.

Quick Overview for Caspase 7 antibody (N-Term) (ABIN187518)

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Caspase 7 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: MCH3-14

Product Details anti-Caspase 7 Antibody

Binding Specificity: N-Term

Sterility: 0.2 μm filtered

Immunogen: Synthetic peptide corresponding to amino acids 1 to 11 of the human caspase-7 enzyme.

Isotype: IgG1

Application Details

Application Notes: Western Blot The optimal dilution for a specific application should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Mouse monoclonal antibody against human Caspase-7 (cysteine-requiring aspartate protease-7). Available in 100 ul vials at a concentration of 1 mg/ml (100ug) in PBS with 0.08% sodium azide. The antibody is 0.2 um sterile filtered.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for Caspase 7

Target: Caspase 7 (CASP7) (Caspase 7, Apoptosis-Related Cysteine Peptidase (CASP7))

Alternative Name: Caspase-7

Background: Caspases are key effectors of programmed cell death. Caspase-7 along with caspase 3 and 6 form the group of effector caspases that are responsible for the cleavage of multiple substrates including the cytokeratins, PARP, alpha lodrin, NuMa and others. Caspase-7 is a 303 amino acid protein with high similarity to caspase-3. Caspase-7 is found in three variant forms. Granzyme B activates pro-caspase-7 to a form which can cleave PARP to its key fragment of about 85 kDa. Also, in vivo caspase-7 appears to be a better substrate for granzyme B than caspase-3. Pro-caspase-7 has been shown to exist as dimers or high order oligomers. Caspase-7 may be an important intracellular effector of granzyme B-medicated apoptosis and cytotoxic T-lymphocyte-induced cell killing in vivo.

Pathways: Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity