LPAR1 antibody (C-Term)

Catalog No. ABIN187787

The Rabbit Polyclonal anti-LPAR1 antibody has been validated for WB. It is suitable to detect LPAR1 in samples from Human and Rat.

Quick Overview for LPAR1 antibody (C-Term) (ABIN187787)

Target: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LPAR1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-LPAR1 Antibody

Binding Specificity: C-Term

Specificity: Reacts with EDG-2. Species Reactivity: Human and Rat. Other species not tested.

Sterility: 0.2 μm filtered

Immunogen: KLH conjugated synthetic peptide corresponding to the AA 328-344 of human EDG-2.

Application Details

Restrictions: For Research Use only

Handling

Buffer: Rabbit polyclonal antibody against human endothelial cell differentiation gene 2 (CT). This antibody is provided as a 0.2 µm sterile-filtered solution in PBS with 0.08% sodium azide at a concentration of 1 mg/mL. Assayed to be >95% purity by SDS PAGE.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Target Details for LPAR1

Target: LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))

Alternative Name: EDG-2 / LPAR1

Background: Endothelial cell differentiation gene-2 (EDG-2) receptor is a high affinity receptor for lysophosphatidic acid (LPA). EDG-2, like all other EDG receptors, couple multiple (3 or more) types of G proteins and transduction decreases in c[AMP]i through Gi and increases in [Ca+2]i by augmenting phospholipase C through Gq/11 and beta/gamma dimers and by induction of PI3 kinase, p125 FAK, phospholipase D by activating rho through G12/13. Human EDG-2 is present in high levels on oligodendrocytes and certain human malignant T cell lines. EDG-2 receptors (with EDG-4) may play a role in protecting cardiomyocytes from apoptosis induced by hypoxia and andrenergic stimulation.

Pathways: Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration