ATG13 antibody (pSer355)

Catalog No. ABIN1881081

This anti-ATG13 antibody is a Rabbit Polyclonal antibody detecting ATG13 in DB. Suitable for Human. This Primary Antibody has been cited in 5+ publications.

Quick Overview for ATG13 antibody (pSer355) (ABIN1881081)

Target: ATG13 (Autophagy Related 13 (ATG13))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATG13 antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB40774

Product Details anti-ATG13 Antibody

Binding Specificity: pSer355

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ATG13 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S355 of human ATG13.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ATG13 antibody (ABIN1881081)

Ferreira, Pan-Hammarström, Graham, Gateva, Fontán, Lee, Ortmann, Urcelay, Fernández-Arquero, Núñez, Jorgensen, Ludviksson, Koskinen, Haimila, Clark, Klareskog, Gregersen, Behrens, Hammarström: "Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency." in: Nature genetics, Vol. 42, Issue 9, pp. 777-80, (2010) (PubMed).

Koh, Lin, Jedd, Wong: "Sirius PSB: a generic system for analysis of biological sequences." in: Journal of bioinformatics and computational biology, Vol. 7, Issue 6, pp. 973-90, (2009) (PubMed).

Mercer, Kaliappan, Dennis: "A novel, human Atg13 binding protein, Atg101, interacts with ULK1 and is essential for macroautophagy." in: Autophagy, Vol. 5, Issue 5, pp. 649-62, (2009) (PubMed).

Ganley, Lam, Wang, Ding, Chen, Jiang: "ULK1.ATG13.FIP200 complex mediates mTOR signaling and is essential for autophagy." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12297-305, (2009) (PubMed).

Chan, Longatti, McKnight, Tooze: "Kinase-inactivated ULK proteins inhibit autophagy via their conserved C-terminal domains using an Atg13-independent mechanism." in: Molecular and cellular biology, Vol. 29, Issue 1, pp. 157-71, (2008) (PubMed).

Target Details for ATG13

Target: ATG13 (Autophagy Related 13 (ATG13))

Alternative Name: ATG13

Background: Autophagy factor required for autophagosome formation. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex.

Molecular Weight: 56572

NCBI Accession: NP_001136145, NP_001192048, NP_001192049, NP_001192050, NP_001192051, NP_055556

UniProt: O75143

Pathways: PI3K-Akt Signaling, Autophagy