BRMS1 antibody (N-Term)

Catalog No. ABIN1881120

Cited in 4+ publications. The Rabbit Polyclonal anti-BRMS1 antibody (Clone RB40250) (ABIN1881120) specifically detects BRMS1 in WB. The antibody is reactive with Human samples.

Quick Overview for BRMS1 antibody (N-Term) (ABIN1881120)

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BRMS1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40250

Product Details anti-BRMS1 Antibody

Binding Specificity: AA 48-77, N-Term

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This BRMS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 48-77 amino acids from the N-terminal region of human BRMS1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-BRMS1 antibody (ABIN1881120)

Wu, McEwen, Harihar, Baker, DeWald, Zhou: "BRMS1 expression alters the ultrastructural, biomechanical and biochemical properties of MDA-MB-435 human breast carcinoma cells: an AFM and Raman microspectroscopy study." in: Cancer letters, Vol. 293, Issue 1, pp. 82-91, (2010) (PubMed).

Vaidya, Sanchez, Kim, Welch: "Expression of the Breast Cancer Metastasis Suppressor 1 (BRMS1) maintains in vitro chemosensitivity of breast cancer cells." in: Cancer letters, Vol. 281, Issue 1, pp. 100-7, (2009) (PubMed).

Frolova, Edmonds, Bodenstine, Seitz, Johnson, Feng, Welch, Frost: "A shift from nuclear to cytoplasmic breast cancer metastasis suppressor 1 expression is associated with highly proliferative estrogen receptor-negative breast cancers." in: Tumour biology, Vol. 30, Issue 3, pp. 148-59, (2009) (PubMed).

Cicek, Fukuyama, Cicek, Sizemore, Welch, Sizemore, Casey: "BRMS1 contributes to the negative regulation of uPA gene expression through recruitment of HDAC1 to the NF-kappaB binding site of the uPA promoter." in: Clinical & experimental metastasis, Vol. 26, Issue 3, pp. 229-37, (2009) (PubMed).

Target Details for BRMS1

Target: BRMS1 (Breast Cancer Metastasis Suppressor 1 (BRMS1))

Alternative Name: BRMS1

Background: This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Molecular Weight: 28461

NCBI Accession: NP_056214

UniProt: Q9HCU9