CASR antibody (AA 260-287)

Catalog No. ABIN1881139

This Rabbit Polyclonal antibody specifically detects CASR in WB. It exhibits reactivity toward Mouse and has been mentioned in 2+ publications.

Quick Overview for CASR antibody (AA 260-287) (ABIN1881139)

Target: CASR (Calcium-Sensing Receptor (CASR))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CASR antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41198

Product Details anti-CASR Antibody

Binding Specificity: AA 260-287

Predicted Reactivity: B, Pig, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CASR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 260-287 amino acids from the Central region of human CASR.

Isotype: IgG

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CASR antibody (ABIN1881139)

OSeaghdha, Yang, Glazer, Leak, Dehghan, Smith, Kao, Lohman, Hwang, Johnson, Hofman, Uitterlinden, Chen, Brown, Siscovick, Harris, Psaty, Coresh, Gudnason, Witteman, Liu, Kestenbaum, Fox, Köttgen: "Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels." in: Human molecular genetics, Vol. 19, Issue 21, pp. 4296-303, (2010) (PubMed).

Giroux, Elfassihi, Clément, Bussières, Bureau, Cole, Rousseau: "High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density." in: Bone, Vol. 47, Issue 5, pp. 975-81, (2010) (PubMed).

Target Details for CASR

Target: CASR (Calcium-Sensing Receptor (CASR))

Alternative Name: CASR

Background: The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism. [provided by RefSeq].

Molecular Weight: 120675

NCBI Accession: NP_000379, NP_001171536

UniProt: P41180

Pathways: Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis