CD46 antibody (AA 330-361)

Catalog No. ABIN1881186

Product Details anti-CD46 Antibody

Target: CD46

Binding Specificity: AA 330-361

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CD46 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 330-361 amino acids from the Central region of human CD46.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CD46 antibody (ABIN1881186)

Riley, Kemper, Leung, Atkinson: "Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa." in: Molecular reproduction and development, Vol. 62, Issue 4, pp. 534-46, (2002) (PubMed).

Cervoni, Fenichel, Akhoundi, Hsi, Rossi: "Characterization of a cDNA clone coding for human testis membrane cofactor protein (MCP, CD46)." in: Molecular reproduction and development, Vol. 34, Issue 1, pp. 107-13, (1993) (PubMed).

Post, Liszewski, Adams, Tedja, Miller, Atkinson: "Membrane cofactor protein of the complement system: alternative splicing of serine/threonine/proline-rich exons and cytoplasmic tails produces multiple isoforms that correlate with protein phenotype." in: The Journal of experimental medicine, Vol. 174, Issue 1, pp. 93-102, (1991) (PubMed).

Purcell, Russell, Deacon, Brown, Hooker, McKenzie: "Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation." in: Immunogenetics, Vol. 33, Issue 5-6, pp. 335-44, (1991) (PubMed).

Lublin, Liszewski, Post, Arce, Le Beau, Rebentisch, Lemons, Seya, Atkinson: "Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins." in: The Journal of experimental medicine, Vol. 168, Issue 1, pp. 181-94, (1988) (PubMed).

Target Details for CD46

Target: CD46

Alternative Name: CD46 (CD46 Products)

Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Molecular Weight: 43747

NCBI Accession: NP_002380, NP_722548, NP_758860, NP_758861, NP_758862, NP_758863, NP_758869, NP_758871

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization