CHM antibody (AA 292-320)

Catalog No. ABIN1881197

Product Details anti-CHM Antibody

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Binding Specificity: AA 292-320

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHM antibody is un-conjugated

Application: Western Blotting (WB)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM.

Clone: RB42411

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CHM antibody (ABIN1881197)

Renner, Fiebig, Cropp, Weber, Kellner: "Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation." in: Archives of ophthalmology, Vol. 127, Issue 7, pp. 907-12, (2009) (PubMed).

Target Details for CHM

Target: CHM (Choroideremia (Rab Escort Protein 1) (CHM))

Alternative Name: CHM (CHM Products)

Background: This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 73476

NCBI Accession: NP_000381, NP_001138886

UniProt: P24386

Pathways: Sensory Perception of Sound