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CHM antibody (Choroideremia (Rab Escort Protein 1)) (AA 292-320) Primary Antibody

CHM Reactivity: Human WB Host: Rabbit Polyclonal RB42411 unconjugated
Pubmed (1)
Catalog No. ABIN1881197
$412.50
Plus shipping costs $45.00
400 μL ABIN1881197
400 μL ABIN1881197
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  • Target
    CHM
    Binding Specificity
    AA 292-320, Center
    • 15
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Reactivity
    Human
    • 39
    • 6
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    Host
    Rabbit
    • 34
    • 5
    Clonality
    Polyclonal
    • 39
    Conjugate
    This CHM antibody is un-conjugated
    • 17
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Application
    Western Blotting (WB)
    • 30
    • 21
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
    Immunogen
    This CHM antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 292-320 amino acids from the Central region of human CHM.
    Clone
    RB42411
  • Application Notes
    WB: 1:1000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    0.27 mg/mL
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
  • Renner, Fiebig, Cropp, Weber, Kellner: "Progression of retinal pigment epithelial alterations during long-term follow-up in female carriers of choroideremia and report of a novel CHM mutation." in: Archives of ophthalmology, Vol. 127, Issue 7, pp. 907-12, 2009 (PubMed).

  • Target
    CHM
    Alternative Name
    CHM (CHM Antibody Abstract)
    Synonyms
    CHM, REP1, DXS540, GGTA, HSD-32, REP-1, TCD, DKFZp459K2154, tcd, ggta, rep-1, dxs540, hsd-32, MGC68578, Rep-1, chm, chm-a, chm-b, chml, CHM, Rab escort protein 1, choroideremia (Rab escort protein 1), choroideremia (Rab escort protein 1) L homeolog, choroidermia (RAB escort protein 1), choroideremia (Rab escort protein 1) S homeolog, CHM, chm, chm.L, Chm, chm.S
    Background
    This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the correct intracellular membrane. Mutations in this gene are a cause of choroideremia, also known as tapetochoroidal dystrophy (TCD). This X-linked disease is characterized by progressive dystrophy of the choroid, retinal pigment epithelium and retina. Alternative splicing results in multiple transcript variants encoding different isoforms.

    Synonyms: CHM, REP1, TCD, Rab proteins geranylgeranyltransferase component A 1, Choroideraemia protein, Rab escort protein 1, TCD protein
    NCBI Accession
    NP_000381, NP_001138886
    UniProt
    P24386
    Pathways
    Sensory Perception of Sound
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