CIB1 antibody (C-Term)

Catalog No. ABIN1881205

This Rabbit Polyclonal antibody specifically detects CIB1 in WB. It exhibits reactivity toward Human and has been mentioned in 5+ publications.

Quick Overview for CIB1 antibody (C-Term) (ABIN1881205)

Target: CIB1 (Calcium and Integrin-Binding Protein 1 (CIB1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CIB1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41938

Product Details anti-CIB1 Antibody

Binding Specificity: AA 122-151, C-Term

Predicted Reactivity: M, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CIB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 122-151 amino acids from the C-terminal region of human CIB1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CIB1 antibody (ABIN1881205)

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Jarman, Moretti, Zebol, Pitson: "Translocation of sphingosine kinase 1 to the plasma membrane is mediated by calcium- and integrin-binding protein 1." in: The Journal of biological chemistry, Vol. 285, Issue 1, pp. 483-92, (2009) (PubMed).

Yamniuk, Anderson, Fraser, Vogel: "Auxiliary Ca2+ binding sites can influence the structure of CIB1." in: Protein science : a publication of the Protein Society, Vol. 18, Issue 5, pp. 1128-34, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Denofrio, Yuan, Temple, Gentry, Parise: "Characterization of calcium- and integrin-binding protein 1 (CIB1) knockout platelets: potential compensation by CIB family members." in: Thrombosis and haemostasis, Vol. 100, Issue 5, pp. 847-56, (2008) (PubMed).

Target Details for CIB1

Target: CIB1 (Calcium and Integrin-Binding Protein 1 (CIB1))

Alternative Name: CIB1

Background: The protein encoded by this gene is a member of the calcium-binding protein family. The specific function of this protein has not yet been determined, however this protein is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining. This protein also interacts with integrin alpha(IIb)beta(3), which may implicate this protein as a regulatory molecule for alpha(IIb)beta(3).

Molecular Weight: 21703

NCBI Accession: NP_006375

UniProt: Q99828