CIB1 antibody

Catalog No. ABIN969057

Cited in 2+ publications. The Mouse Monoclonal anti-CIB1 antibody (Clone 5A1F5E12) (ABIN969057) specifically detects CIB1 in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for CIB1 antibody (ABIN969057)

Target: CIB1 (Calcium and Integrin-Binding Protein 1 (CIB1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CIB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 5A1F5E12

Product Details anti-CIB1 Antibody

Purpose: CIB1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of CIB1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CIB1 antibody (ABIN969057)

White, Yang, Monteiro, Foskett: "CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channel." in: The Journal of biological chemistry, Vol. 281, Issue 30, pp. 20825-33, (2006) (PubMed).

Gentry, Singer, Betts, Yang, Ferrara, Sondek, Parise: "Structural and biochemical characterization of CIB1 delineates a new family of EF-hand-containing proteins." in: The Journal of biological chemistry, Vol. 280, Issue 9, pp. 8407-15, (2005) (PubMed).

Target Details for CIB1

Target: CIB1 (Calcium and Integrin-Binding Protein 1 (CIB1))

Alternative Name: CIB1

Background: CIB1(also designated calcium and integrin binding 1 or calmyrin),with 191-amino acid protein(about 21 kDa), belongs to the calcium-binding protein family.CIB1 is known to interact with DNA-dependent protein kinase and may play a role in kinase-phosphatase regulation of DNA end joining.CIB1 is an EF-hand-containing protein that binds multiple effector proteins, including the platelet alpha(IIb)beta(3) integrin and several serine/threonine kinases and potentially modulates their function.CIB1 regulates platelet aggregation in hemostasis through a specific interaction with the alpha(IIb) cytoplasmic domain of platelet integrin alpha(IIb)beta(3). CIB1 is also ubiquitously expressed activating and inhibiting protein ligand of the InsP3R.

UniProt: Q99828