DHODH antibody (AA 166-194)

Catalog No. ABIN1881259

This Rabbit Polyclonal antibody specifically detects DHODH in WB. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for DHODH antibody (AA 166-194) (ABIN1881259)

Target: DHODH (Dihydroorotate Dehydrogenase (DHODH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DHODH antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40540

Product Details anti-DHODH Antibody

Binding Specificity: AA 166-194

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DHODH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-194 amino acids from the Central region of human DHODH.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-DHODH antibody (ABIN1881259)

Hail, Chen, Kepa, Bushman, Shearn: "Dihydroorotate dehydrogenase is required for N-(4-hydroxyphenyl)retinamide-induced reactive oxygen species production and apoptosis." in: Free radical biology & medicine, Vol. 49, Issue 1, pp. 109-16, (2010) (PubMed).

Ng, Buckingham, Lee, Bigham, Tabor, Dent, Huff, Shannon, Jabs, Nickerson, Shendure, Bamshad: "Exome sequencing identifies the cause of a mendelian disorder." in: Nature genetics, Vol. 42, Issue 1, pp. 30-5, (2009) (PubMed).

Grabar, Rozman, Logar, Praprotnik, Dolzan: "Dihydroorotate dehydrogenase polymorphism influences the toxicity of leflunomide treatment in patients with rheumatoid arthritis." in: Annals of the rheumatic diseases, Vol. 68, Issue 8, pp. 1367-8, (2009) (PubMed).

Pawlik, Herczynska, Kurzawski, Safranow, Dziedziejko, Drozdzik: "The effect of exon (19C>A) dihydroorotate dehydrogenase gene polymorphism on rheumatoid arthritis treatment with leflunomide." in: Pharmacogenomics, Vol. 10, Issue 2, pp. 303-9, (2009) (PubMed).

Target Details for DHODH

Target: DHODH (Dihydroorotate Dehydrogenase (DHODH))

Alternative Name: DHODH

Background: The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane.

Molecular Weight: 42867

NCBI Accession: NP_001352

UniProt: Q02127

Pathways: Ribonucleoside Biosynthetic Process, Protein targeting to Nucleus