ECE2 antibody (AA 551-579)

Catalog No. ABIN1881279

Product Details anti-ECE2 Antibody

Target: ECE2 (Endothelin Converting Enzyme 2 (ECE2))

Binding Specificity: AA 551-579

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Predicted Reactivity: B, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ECE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 551-579 amino acids from the Central region of human ECE2.

Clone: RB43866

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:25

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ECE2 antibody (ABIN1881279)

Muzny, Scherer, Kaul, Wang, Yu, Sudbrak, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker et al.: "The DNA sequence, annotation and analysis of human chromosome 3. ..." in: Nature, Vol. 440, Issue 7088, pp. 1194-8, (2006) (PubMed).

Lorenzo, Khan, Wang, Tai, Chan, Cheung, Marsden: "Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization." in: Biochimica et biophysica acta, Vol. 1522, Issue 1, pp. 46-52, (2001) (PubMed).

Nagase, Ishikawa, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 1, pp. 31-9, (1998) (PubMed).

Target Details for ECE2

Target: ECE2 (Endothelin Converting Enzyme 2 (ECE2))

Alternative Name: ECE2 (ECE2 Products)

Background: Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.

NCBI Accession: NP_001032401, NP_001093590, NP_001093591, NP_055508, NP_115707

UniProt: O60344

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling