ECE2 antibody

Catalog No. ABIN7228344

The Rabbit Polyclonal anti-ECE2 antibody is suitable to detect ECE2 in samples from Human and Mouse. It has been validated for WB and ELISA.

Quick Overview for ECE2 antibody (ABIN7228344)

Target: ECE2 (Endothelin Converting Enzyme 2 (ECE2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECE2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-ECE2 Antibody

Purpose: Rabbit Anti-ECE2 Polyclonal Antibody

Specificity: The antibody detects endogenous levels of ECE2 protein

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from part region of human ECE2 protein

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-2000,ELISA 1:5000-20000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 %BSA

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for ECE2

Target: ECE2 (Endothelin Converting Enzyme 2 (ECE2))

Alternative Name: ECE2

Background: Endothelin-converting enzyme 2ECE2 (Endothelin Converting Enzyme 2) is a Protein Coding gene. Among its related pathways are A-beta Pathways: uptake and Degradation and Peptide ligand-binding receptors. GO annotations related to this gene include methyltransferase activity and metalloendopeptidase activity. An important paralog of this gene is ECE1. Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity.

Molecular Weight: 97kD

Gene ID: 9718

UniProt: O60344

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling