EPC1 antibody (AA 305-334)

Catalog No. ABIN1881300

This anti-EPC1 antibody is a Rabbit Polyclonal antibody detecting EPC1 in WB. Suitable for Human and Mouse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for EPC1 antibody (AA 305-334) (ABIN1881300)

Target: EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPC1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-EPC1 Antibody

Binding Specificity: AA 305-334

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This EPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-334 amino acids from the Central region of human EPC1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-EPC1 antibody (ABIN1881300)

Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: "The DNA sequence and comparative analysis of human chromosome 10. ..." in: Nature, Vol. 429, Issue 6990, pp. 375-81, (2004) (PubMed).

Shimono, Murakami, Hasegawa, Takahashi: "RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39411-9, (2001) (PubMed).

Target Details for EPC1

Target: EPC1 (Enhancer of Polycomb Homolog 1 (EPC1))

Alternative Name: EPC1

Background: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome -DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage.

Molecular Weight: 93463

NCBI Accession: NP_001258933, NP_001258948, NP_001269320, NP_079485

UniProt: Q9H2F5

Pathways: Regulation of Muscle Cell Differentiation