ESR2 antibody (AA 211-240)

Catalog No. ABIN1881322

This Rabbit Polyclonal antibody specifically detects ESR2 in WB. It exhibits reactivity toward Human and Mouse and has been mentioned in 2+ publications.

Quick Overview for ESR2 antibody (AA 211-240) (ABIN1881322)

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ESR2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41114

Product Details anti-ESR2 Antibody

Binding Specificity: AA 211-240

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ESR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-240 amino acids from the Central region of human ESR2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-ESR2 antibody (ABIN1881322)

Fang, Lu, Wang, Wu, Li, Zhang, Pan, Wan: "Prognostic impact of ERβ and MMP7 expression on overall survival in colon cancer." in: Tumour biology, Vol. 31, Issue 6, pp. 651-8, (2010) (PubMed).

Hayes, Skaar, Rae, Henry, Nguyen, Stearns, Li, Philips, Desta, Flockhart: "Estrogen receptor genotypes, menopausal status, and the effects of tamoxifen on lipid levels: revised and updated results." in: Clinical pharmacology and therapeutics, Vol. 88, Issue 5, pp. 626-9, (2010) (PubMed).

Target Details for ESR2

Target: ESR2 (Estrogen Receptor 2 (ESR2))

Alternative Name: ESR2

Background: This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.

Molecular Weight: 59216

NCBI Accession: NP_001035365, NP_001201831, NP_001201832, NP_001258805, NP_001258806, NP_001428

UniProt: Q92731

Pathways: Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling