FXR1 antibody (N-Term)

Catalog No. ABIN1881357

Cited in 5+ publications. The Rabbit Polyclonal anti-FXR1 antibody (Clone RB41819) (ABIN1881357) specifically detects FXR1 in WB. The antibody is reactive with Mouse samples.

Quick Overview for FXR1 antibody (N-Term) (ABIN1881357)

Target: FXR1 (Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FXR1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB41819

Product Details anti-FXR1 Antibody

Binding Specificity: AA 37-66, N-Term

Predicted Reactivity: B, Ha, Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This FXR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-66 amino acids from the N-terminal region of human FXR1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-FXR1 antibody (ABIN1881357)

Coffee, Tessier, Woodruff, Broadie: "Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P." in: Disease models & mechanisms, Vol. 3, Issue 7-8, pp. 471-85, (2010) (PubMed).

Darnell, Fraser, Mostovetsky, Darnell: "Discrimination of common and unique RNA-binding activities among Fragile X mental retardation protein paralogs." in: Human molecular genetics, Vol. 18, Issue 17, pp. 3164-77, (2009) (PubMed).

Purcell, Wray, Stone, Visscher, ODonovan, Sullivan, Sklar: "Common polygenic variation contributes to risk of schizophrenia and bipolar disorder." in: Nature, Vol. 460, Issue 7256, pp. 748-52, (2009) (PubMed).

Davidovic, Sacconi, Bechara, Delplace, Allegra, Desnuelle, Bardoni: "Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients." in: Journal of medical genetics, Vol. 45, Issue 10, pp. 679-85, (2008) (PubMed).

Vasudevan, Steitz: "AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2." in: Cell, Vol. 128, Issue 6, pp. 1105-18, (2007) (PubMed).

Target Details for FXR1

Target: FXR1 (Fragile X Mental Retardation, Autosomal Homolog 1 (FXR1))

Alternative Name: FXR1

Background: The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 69721

NCBI Accession: NP_001013456, NP_001013457, NP_005078

UniProt: P51114