HLA-DQA2 antibody (AA 39-66)

Catalog No. ABIN1881421

This Rabbit Polyclonal antibody specifically detects HLA-DQA2 in WB. It exhibits reactivity toward Human. It has been mentioned in 4+ publications

Quick Overview for HLA-DQA2 antibody (AA 39-66) (ABIN1881421)

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HLA-DQA2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42054

Product Details anti-HLA-DQA2 Antibody

Binding Specificity: AA 39-66

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This HLA-DQA2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-66 amino acids from the Central region of human HLA-DQA2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-HLA-DQA2 antibody (ABIN1881421)

Hor, Kutalik, Dauvilliers, Valsesia, Lammers, Donjacour, Iranzo, Santamaria, Peraita Adrados, Vicario, Overeem, Arnulf, Theodorou, Jennum, Knudsen, Bassetti: "Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy." in: Nature genetics, Vol. 42, Issue 9, pp. 786-9, (2010) (PubMed).

Petukhova, Duvic, Hordinsky, Norris, Price, Shimomura, Kim, Singh, Lee, Chen, Meyer, Paus, Jahoda, Amos, Gregersen, Christiano: "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity." in: Nature, Vol. 466, Issue 7302, pp. 113-7, (2010) (PubMed).

Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, (2010) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Target Details for HLA-DQA2

Target: HLA-DQA2 (Major Histocompatibility Complex, Class II, DQ alpha 2 (HLA-DQA2))

Alternative Name: HLA-DQA2

Background: This gene belongs to the HLA class II alpha chain family. The encoded protein forms a heterodimer with a class II beta chain. It is located in intracellular vesicles and plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages) and are used to present antigenic peptides on the cell surface to be recognized by CD4 T-cells. [provided by RefSeq].

Molecular Weight: 28033

NCBI Accession: NP_064440

UniProt: P01906

Pathways: TCR Signaling, Human Leukocyte Antigen (HLA) in Adaptive Immune Response