KCNMB2 antibody (N-Term)

Catalog No. ABIN1881476

There are 5+ publications for this product available. The Rabbit Polyclonal anti-KCNMB2 antibody is suitable to detect KCNMB2 in samples from Human. It has been validated for WB.

Quick Overview for KCNMB2 antibody (N-Term) (ABIN1881476)

Target: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNMB2 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42799

Product Details anti-KCNMB2 Antibody

Binding Specificity: AA 1-30, N-Term

Predicted Reactivity: Rat

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KCNMB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human KCNMB2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-KCNMB2 antibody (ABIN1881476)

Treviño, Yang, French, Hunger, Carroll, Devidas, Willman, Neale, Downing, Raimondi, Pui, Evans, Relling: "Germline genomic variants associated with childhood acute lymphoblastic leukemia." in: Nature genetics, Vol. 41, Issue 9, pp. 1001-5, (2009) (PubMed).

Lee, Cui: "{beta} subunit-specific modulations of BK channel function by a mutation associated with epilepsy and dyskinesia." in: The Journal of physiology, Vol. 587, Issue Pt 7, pp. 1481-98, (2009) (PubMed).

Zarei, Song, Wilson, Cox, Colom, Knaus, Stefani, Toro: "Endocytic trafficking signals in KCNMB2 regulate surface expression of a large conductance voltage and Ca(2+)-activated K+ channel." in: Neuroscience, Vol. 147, Issue 1, pp. 80-9, (2007) (PubMed).

Zeng, Benzinger, Xia, Lingle: "BK channels with beta3a subunits generate use-dependent slow afterhyperpolarizing currents by an inactivation-coupled mechanism." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 27, Issue 17, pp. 4707-15, (2007) (PubMed).

Orio, Torres, Rojas, Carvacho, Garcia, Toro, Valverde, Latorre: "Structural determinants for functional coupling between the beta and alpha subunits in the Ca2+-activated K+ (BK) channel." in: The Journal of general physiology, Vol. 127, Issue 2, pp. 191-204, (2006) (PubMed).

Target Details for KCNMB2

Target: KCNMB2 (Potassium Large Conductance Calcium-Activated Channel, Subfamily M, beta Member 2 (KCNMB2))

Alternative Name: KCNMB2

Background: MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Two variants encoding the same protein have been found for this gene. [provided by RefSeq].

Molecular Weight: 27130

NCBI Accession: NP_001265840, NP_005823, NP_852006

UniProt: Q9Y691