Netrin 1 antibody (C-Term)

Catalog No. ABIN1881590

There are 4+ publications for this product available. The Rabbit Polyclonal anti-Netrin 1 antibody is suitable to detect Netrin 1 in samples from Human. It has been validated for WB.

Quick Overview for Netrin 1 antibody (C-Term) (ABIN1881590)

Target: Netrin 1 (NTN1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Netrin 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB44404

Product Details anti-Netrin 1 Antibody

Binding Specificity: AA 568-596, C-Term

Predicted Reactivity: C, M, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NTN1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 568-596 amino acids from the C-terminal region of human NTN1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-Netrin 1 antibody (ABIN1881590)

Li, Liu, Wang, Liu, Liu, Li, Wan, Wang, Zhang, Jin, Liu, Zhu, Liu: "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins." in: Molecular & cellular proteomics : MCP, Vol. 9, Issue 11, pp. 2517-28, (2010) (PubMed).

Liu, Li, Wang, Kar, Guan, Rao, Wu: "DSCAM functions as a netrin receptor in commissural axon pathfinding." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 8, pp. 2951-6, (2009) (PubMed).

Mazelin, Bernet, Bonod-Bidaud, Pays, Arnaud, Gespach, Bredesen, Scoazec, Mehlen: "Netrin-1 controls colorectal tumorigenesis by regulating apoptosis." in: Nature, Vol. 431, Issue 7004, pp. 80-4, (2004) (PubMed).

Meyerhardt, Caca, Eckstrand, Hu, Lengauer, Banavali, Look, Fearon: "Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomas." in: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 10, Issue 1, pp. 35-42, (1999) (PubMed).

Target Details for Netrin 1

Target: Netrin 1 (NTN1)

Alternative Name: NTN1

Background: Netrins control guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Involved in tumorigenesis by regulating apoptosis.

Molecular Weight: 67748

NCBI Accession: NP_004813

UniProt: O95631

Pathways: Regulation of Cell Size