CDKN1B antibody (pThr170)

Catalog No. ABIN1881623

The Rabbit Polyclonal anti-CDKN1B antibody has been validated for DB. It is suitable to detect CDKN1B in samples from Human. There are 4+ publications available.

Quick Overview for CDKN1B antibody (pThr170) (ABIN1881623)

Target: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDKN1B antibody is un-conjugated

Application: Dot Blot (DB)

Clone: RB42119

Product Details anti-CDKN1B Antibody

Binding Specificity: pThr170

Predicted Reactivity: Ha, M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This p27Kip1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding T170 of human p27Kip1.

Isotype: Ig Fraction

Application Details

Application Notes: DB: 1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-CDKN1B antibody (ABIN1881623)

Kajihara, Fukushige, Shioda, Tanabe, Fukunaga, Inui: "CaMKII phosphorylates serine 10 of p27 and confers apoptosis resistance to HeLa cells." in: Biochemical and biophysical research communications, Vol. 401, Issue 3, pp. 350-5, (2010) (PubMed).

Kedde, van Kouwenhove, Zwart, Oude Vrielink, Elkon, Agami: "A Pumilio-induced RNA structure switch in p27-3' UTR controls miR-221 and miR-222 accessibility." in: Nature cell biology, Vol. 12, Issue 10, pp. 1014-20, (2010) (PubMed).

Canbay, Eraltan, Cercel, Isbir, Gazioglu, Aydogan, Cacina, Cengiz, Ferahman, Zengin, Unal: "CCND1 and CDKN1B polymorphisms and risk of breast cancer." in: Anticancer research, Vol. 30, Issue 7, pp. 3093-8, (2010) (PubMed).

Do Nascimento Borges, Burbano, Harada: "Absence of CIP1/KIP1 hypermethylation in gastric cancer patients from Northern Brazil." in: In vivo (Athens, Greece), Vol. 24, Issue 4, pp. 579-82, (2010) (PubMed).

Target Details for CDKN1B

Target: CDKN1B (Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))

Alternative Name: p27Kip1

Background: This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. [provided by RefSeq].

Molecular Weight: 22073

NCBI Accession: NP_004055

UniProt: P46527

Pathways: Cell Division Cycle, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Negative Regulation of Hormone Secretion, Sensory Perception of Sound, Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Synthesis of DNA, Autophagy