PDE6H antibody (AA 4-33)

Catalog No. ABIN1881645

Cited in 4+ publications. The Rabbit Polyclonal anti-PDE6H antibody (Clone RB40887) (ABIN1881645) specifically detects PDE6H in WB. The antibody is reactive with Mouse samples.

Quick Overview for PDE6H antibody (AA 4-33) (ABIN1881645)

Target: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDE6H antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40887

Product Details anti-PDE6H Antibody

Binding Specificity: AA 4-33

Predicted Reactivity: B, Rat, H

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE6H antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 4-33 amino acids from the Central region of human PDE6H.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PDE6H antibody (ABIN1881645)

Piri, Gao, Danciger, Mendoza, Fishman, Farber: "A substitution of G to C in the cone cGMP-phosphodiesterase gamma subunit gene found in a distinctive form of cone dystrophy." in: Ophthalmology, Vol. 112, Issue 1, pp. 159-66, (2005) (PubMed).

Kajimura, Yamazaki, Morikawa, Yamazaki, Mayanagi: "Three-dimensional structure of non-activated cGMP phosphodiesterase 6 and comparison of its image with those of activated forms." in: Journal of structural biology, Vol. 139, Issue 1, pp. 27-38, (2002) (PubMed).

Shimizu-Matsumoto, Itoh, Inazawa, Nishida, Matsumoto, Kinoshita, Matsubara, Okubo: "Isolation and chromosomal localization of the human cone cGMP phosphodiesterase gamma cDNA (PDE6H)." in: Genomics, Vol. 32, Issue 1, pp. 121-4, (1996) (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, (1996) (PubMed).

Target Details for PDE6H

Target: PDE6H (phosphodiesterase 6H, CGMP-Specific, Cone, gamma (PDE6H))

Alternative Name: PDE6H

Background: This gene encodes the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma). It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A).

Molecular Weight: 9074

NCBI Accession: NP_006196

UniProt: Q13956

Pathways: EGFR Signaling Pathway, Regulation of G-Protein Coupled Receptor Protein Signaling