PPP2R1A antibody (C-Term)

Catalog No. ABIN1881682

Product Details anti-PPP2R1A Antibody

Target: PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, alpha (PPP2R1A))

Binding Specificity: AA 454-481, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PPP2R1A antibody is un-conjugated

Application: Western Blotting (WB)

Predicted Reactivity: B, M, Pig

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PPP2R1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 454-481 amino acids from the C-terminal region of human PPP2R1A.

Clone: RB41029

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PPP2R1A antibody (ABIN1881682)

Jones, Wang, Shih, Mao, Nakayama, Roden, Glas, Slamon, Diaz, Vogelstein, Kinzler, Velculescu, Papadopoulos: "Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma." in: Science (New York, N.Y.), Vol. 330, Issue 6001, pp. 228-31, (2010) (PubMed).

Schmitz, Held, Janssens, Hutchins, Hudecz, Ivanova, Goris, Trinkle-Mulcahy, Lamond, Poser, Hyman, Mechtler, Peters, Gerlich: "Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells." in: Nature cell biology, Vol. 12, Issue 9, pp. 886-93, (2010) (PubMed).

Dupont, Breyer, Bradley, Schuyler, Plummer, Sanders, Page, Smith: "Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk." in: Cancer, Vol. 116, Issue 1, pp. 8-19, (2010) (PubMed).

Heikkinen, Nummela, Leivonen, Westermarck, Hill, Kähäri, Jaakkola: "Hypoxia-activated Smad3-specific dephosphorylation by PP2A." in: The Journal of biological chemistry, Vol. 285, Issue 6, pp. 3740-9, (2010) (PubMed).

Wang, Gao, Wang, Flagg, Deng: "A nonhomologous end-joining pathway is required for protein phosphatase 2A promotion of DNA double-strand break repair." in: Neoplasia (New York, N.Y.), Vol. 11, Issue 10, pp. 1012-21, (2009) (PubMed).

Target Details for PPP2R1A

Target: PPP2R1A (Protein Phosphatase 2, Regulatory Subunit A, alpha (PPP2R1A))

Alternative Name: PPP2R1A (PPP2R1A Products)

Background: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq].

Molecular Weight: 65309

NCBI Accession: NP_055040

UniProt: P30153

Pathways: PI3K-Akt Signaling, Mitotic G1-G1/S Phases, M Phase, Hepatitis C, Toll-Like Receptors Cascades