PTBP1 antibody (N-Term)

Catalog No. ABIN1881702

This anti-PTBP1 antibody is a Rabbit Polyclonal antibody detecting PTBP1 in WB. Suitable for Human. This Primary Antibody has been cited in 5+ publications.

Quick Overview for PTBP1 antibody (N-Term) (ABIN1881702)

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTBP1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40967

Product Details anti-PTBP1 Antibody

Binding Specificity: AA 26-55, N-Term

Predicted Reactivity: B

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PTBP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human PTBP1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000. IHC-P: 1:4000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-PTBP1 antibody (ABIN1881702)

Osada, Uno, Mineta, Kameoka, Takahashi, Terao: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." in: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).

Kanda, Gauss-Müller, Cordes, Tamura, Okitsu, Shuang, Nakamoto, Fujiwara, Imazeki, Yokosuka: "Hepatitis A virus (HAV) proteinase 3C inhibits HAV IRES-dependent translation and cleaves the polypyrimidine tract-binding protein." in: Journal of viral hepatitis, Vol. 17, Issue 9, pp. 618-23, (2010) (PubMed).

Verma, Bhattacharyya, Das: "Polypyrimidine tract-binding protein interacts with coxsackievirus B3 RNA and influences its translation." in: The Journal of general virology, Vol. 91, Issue Pt 5, pp. 1245-55, (2010) (PubMed).

Maynard, Hall: "Interactions between PTB RRMs induce slow motions and increase RNA binding affinity." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 260-77, (2010) (PubMed).

Xue, Zhou, Wu, Zhu, Ji, Kwon, Zhang, Yeo, Black, Sun, Fu, Zhang: "Genome-wide analysis of PTB-RNA interactions reveals a strategy used by the general splicing repressor to modulate exon inclusion or skipping." in: Molecular cell, Vol. 36, Issue 6, pp. 996-1006, (2010) (PubMed).

Target Details for PTBP1

Target: PTBP1 (Polypyrimidine Tract Binding Protein 1 (PTBP1))

Alternative Name: PTBP1

Background: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA-binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has four repeats of quasi-RNA recognition motif (RRM) domains that bind RNAs. This protein binds to the intronic polypyrimidine tracts that requires pre-mRNA splicing and acts via the protein degradation ubiquitin-proteasome pathway. It may also promote the binding of U2 snRNP to pre-mRNAs. This protein is localized in the nucleoplasm and it is also detected in the perinucleolar structure. Alternatively spliced transcript variants encoding different isoforms have been described.

Molecular Weight: 57221

NCBI Accession: NP_002810, NP_114367, NP_114368

UniProt: P26599

Pathways: Regulation of Muscle Cell Differentiation