RRM1 antibody (N-Term)

Catalog No. ABIN1881767

There are 2+ publications for this product available. The Rabbit Polyclonal anti-RRM1 antibody is suitable to detect RRM1 in samples from Human. It has been validated for WB.

Quick Overview for RRM1 antibody (N-Term) (ABIN1881767)

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42407

Product Details anti-RRM1 Antibody

Binding Specificity: AA 71-100, N-Term

Predicted Reactivity: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-RRM1 antibody (ABIN1881767)

Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Target Details for RRM1

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Alternative Name: RRM1

Background: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Molecular Weight: 90070

NCBI Accession: NP_001024

UniProt: P23921

Pathways: Positive Regulation of Endopeptidase Activity