SCNN1B antibody (AA 306-332)

Catalog No. ABIN1881778

This Rabbit Polyclonal antibody specifically detects SCNN1B in WB. It exhibits reactivity toward Human. It has been mentioned in 3+ publications

Quick Overview for SCNN1B antibody (AA 306-332) (ABIN1881778)

Target: SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SCNN1B antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42043

Product Details anti-SCNN1B Antibody

Binding Specificity: AA 306-332

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SCNN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-332 amino acids from the Central region of human SCNN1B.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-SCNN1B antibody (ABIN1881778)

Song, Wei, Zhou, Lazrak, Liu, Londino, Squadrito, Matalon: "Inhibition of lung fluid clearance and epithelial Na+ channels by chlorine, hypochlorous acid, and chloramines." in: The Journal of biological chemistry, Vol. 285, Issue 13, pp. 9716-28, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Azad, Rauh, Vermeulen, Jaspers, Korbmacher, Boissier, Bassinet, Fichou, des Georges, Stanke, De Boeck, Dupont, Balascáková, Hjelte, Lebecque: "Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease." in: Human mutation, Vol. 30, Issue 7, pp. 1093-103, (2009) (PubMed).

Target Details for SCNN1B

Target: SCNN1B (Sodium Channel, Nonvoltage-Gated 1, beta (SCNN1B))

Alternative Name: SCNN1B

Background: Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.

Molecular Weight: 72659

NCBI Accession: NP_000327

UniProt: P51168