TSC1 antibody (AA 395-424)

Catalog No. ABIN1881924

The Rabbit Polyclonal anti-TSC1 antibody (Clone RB42204) (ABIN1881924) specifically detects TSC1 in WB. The antibody is reactive with Human samples.

Quick Overview for TSC1 antibody (AA 395-424) (ABIN1881924)

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TSC1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB42204

Product Details anti-TSC1 Antibody

Binding Specificity: AA 395-424

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the Central region of human TSC1.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

Target Details for TSC1

Target: TSC1 (Tuberous Sclerosis 1 (TSC1))

Alternative Name: TSC1

Background: In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.

Molecular Weight: 129767

NCBI Accession: NP_000359, NP_001155898, NP_001155899

UniProt: Q92574

Pathways: RTK Signaling, AMPK Signaling, Regulation of Cell Size, Tube Formation