WASP antibody (AA 205-234)

Catalog No. ABIN1881997

This Rabbit Polyclonal antibody specifically detects WASP in WB. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for WASP antibody (AA 205-234) (ABIN1881997)

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WASP antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40707

Product Details anti-WASP Antibody

Binding Specificity: AA 205-234

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This WAS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 205-234 amino acids from the Central region of human WAS.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-WASP antibody (ABIN1881997)

Almgren, Garamus, Nordstierna, Luc-Blin, Stébé: "Nonideal mixed micelles of fluorinated and hydrogenous surfactants in aqueous solution. NMR and SANS studies of anionic and nonionic systems." in: Langmuir : the ACS journal of surfaces and colloids, Vol. 26, Issue 8, pp. 5355-63, (2010) (PubMed).

Dovas, Gevrey, Grossi, Park, Abou-Kheir, Cox: "Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages." in: Journal of cell science, Vol. 122, Issue Pt 21, pp. 3873-82, (2009) (PubMed).

Ameratunga, Woon: "Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country." in: The New Zealand medical journal, Vol. 122, Issue 1304, pp. 46-53, (2009) (PubMed).

Target Details for WASP

Target: WASP (WAS) (Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS))

Alternative Name: WAS

Background: The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known.

Molecular Weight: 52913

NCBI Accession: NP_000368

UniProt: P42768