XPC antibody (N-Term)

Catalog No. ABIN1882000

This Rabbit Polyclonal antibody specifically detects XPC in WB. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for XPC antibody (N-Term) (ABIN1882000)

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This XPC antibody is un-conjugated

Application: Western Blotting (WB)

Clone: RB40964

Product Details anti-XPC Antibody

Binding Specificity: AA 154-183, N-Term

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This XPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 154-183 amino acids from the N-terminal region of human XPC.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Expiry Date: 6 months

References for anti-XPC antibody (ABIN1882000)

Stern, Lin, Figueroa, Kelsey, Kiltie, Yuan, Matullo, Fletcher, Benhamou, Taylor, Placidi, Zhang, Steineck, Rothman, Kogevinas, Silverman, Malats, Chanock, Wu, Karagas: "Polymorphisms in DNA repair genes, smoking, and bladder cancer risk: findings from the international consortium of bladder cancer." in: Cancer research, Vol. 69, Issue 17, pp. 6857-64, (2009) (PubMed).

Target Details for XPC

Target: XPC (Xeroderma Pigmentosum, Complementation Group C (XPC))

Alternative Name: XPC

Background: This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight: 105953

NCBI Accession: NP_001139241, NP_004619

UniProt: Q01831

Pathways: p53 Signaling, DNA Damage Repair