Dual Specificity Phosphatase 3 (DUSP3) (AA 1-150) antibody

Catalog No. ABIN1885645

This Rabbit Polyclonal antibody specifically detects in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Dual Specificity Phosphatase 3 (DUSP3) (AA 1-150) antibody (ABIN1885645)

Target: Dual Specificity Phosphatase 3 (DUSP3)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details

Binding Specificity: AA 1-150

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 150 of Human DUSP3

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details

Target: Dual Specificity Phosphatase 3 (DUSP3)

Alternative Name: VHR

Background: The protein encoded by this gene is a member of the dualprotein phosphatase subfamily.These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues.They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation.Different members of the family of dual phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli.This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer.Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.[provided by RefSeq]

Molecular Weight: 20 kDa

Gene ID: 1845

NCBI Accession: NP_004081, NM_004090

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades