The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family.All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein.This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion.It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.Several transcript variants encoding the same protein have been found for this gene.[provided by RefSeq]