DNASE1 antibody (AA 1-252)

Catalog No. ABIN1885847

The Rabbit Polyclonal anti-DNASE1 antibody is suitable to detect DNASE1 in samples from Human. It has been validated for WB and IF.

Quick Overview for DNASE1 antibody (AA 1-252) (ABIN1885847)

Target: DNASE1 (Deoxyribonuclease I (DNASE1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DNASE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-DNASE1 Antibody

Binding Specificity: AA 1-252

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 252 of DNase I

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for DNASE1

Target: DNASE1 (Deoxyribonuclease I (DNASE1))

Alternative Name: DNase I

Background: This gene encodes a member of the DNase family.This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner.At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record.Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease.A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity.Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[provided by RefSeq]

Molecular Weight: 31 kDa

Gene ID: 1773

NCBI Accession: NM_005223, NP_005214