ALPL antibody (AA 1-369)

Catalog No. ABIN1885918

This Rabbit Polyclonal antibody specifically detects ALPL in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for ALPL antibody (AA 1-369) (ABIN1885918)

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALPL antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-ALPL Antibody

Binding Specificity: AA 1-369

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 369 of alkaline phosphatase (liver/bone/kidney)

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for ALPL

Target: ALPL (Alkaline Phosphatase, Liver/bone/kidney (ALPL))

Alternative Name: alkaline phosphatase(liver/bone/kidney)

Background: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific).The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1.The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme.The exact physiological function of the alkaline phosphatases is not known.A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development.This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects.The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms.Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.[provided by RefSeq]

Molecular Weight: 57 kDa

Gene ID: 249

NCBI Accession: NM_000478, NP_000469