RASGRP4 antibody (AA 108-170)

Catalog No. ABIN1885956

This anti-RASGRP4 antibody is a Rabbit Polyclonal antibody detecting RASGRP4 in WB, IHC and IF. Suitable for Human.

Quick Overview for RASGRP4 antibody (AA 108-170) (ABIN1885956)

Target: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RASGRP4 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-RASGRP4 Antibody

Binding Specificity: AA 108-170

Purification: Purified by antigen-affinity chromatography.

Immunogen: Synthetic peptide contain a sequence corresponding to a region within amino acids 108 and 170 of Human RASGRP4

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for RASGRP4

Target: RASGRP4 (RAS Guanyl Releasing Protein 4 (RASGRP4))

Alternative Name: RASGRP4

Background: The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors.It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands.This protein was shown to activate H-Ras in a cation-dependent manner in vitro.Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways.Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development.Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]

Molecular Weight: 75 kDa

Gene ID: 115727

NCBI Accession: NM_170604, NP_733749

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling