Dynactin 1 antibody (AA 1216-1278)
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- Target See all Dynactin 1 (DCTN1) Antibodies
- Dynactin 1 (DCTN1)
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Binding Specificity
- AA 1216-1278
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This Dynactin 1 antibody is un-conjugated
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
- Purification
- Purified by antigen-affinity chromatography.
- Immunogen
- Synthetic peptide contain a sequence corresponding to a region within amino acids 1216 and 1278 of dynactin 1
- Top Product
- Discover our top product DCTN1 Primary Antibody
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- Application Notes
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Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200 - Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- 1 x PBS, 1 % BSA, 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.
- Preservative
- Thimerosal (Merthiolate)
- Precaution of Use
- Biohazard Informations: This product contains thimerosal which is hazardous.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- Target
- Dynactin 1 (DCTN1)
- Alternative Name
- dynactin 1 (DCTN1 Products)
- Synonyms
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DAP-150 antibody, DP-150 antibody, P135 antibody, Chip150 antibody, DCTN1 antibody, DKFZp469C1813 antibody, AL022633 antibody, Glued antibody, p150 antibody, p150
antibody, CG9206 antibody, DYNA_DROME antibody, Dmel\\CG9206 antibody, FCP-D antibody, Glu antibody, P150 antibody, P150[Glued] antibody, p150/Glued antibody, p150/glued antibody, p150[Glued] antibody, p150[glued] antibody, t1 antibody, Dynactin-1 antibody, glued antibody, dynactin subunit 1 antibody, dynactin 1 antibody, Dynactin 1, p150 subunit antibody, dynactin subunit 1 L homeolog antibody, DCTN1 antibody, Dctn1 antibody, DCTN1-p150 antibody, dctn1.L antibody - Background
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This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD.Dynactin binds to both microtubules and cytoplasmic dynein.Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis.This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus.Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) which is also known as distal spinal and bulbar muscular atrophy (dSBMA).[provided by RefSeq]
- Molecular Weight
- 142 kDa
- Gene ID
- 1639
- NCBI Accession
- NP_004073, NM_004082
- Pathways
- M Phase, ER-Nucleus Signaling
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