C5 antibody (AA 1223-1421)

Catalog No. ABIN1885991

The Rabbit Polyclonal anti-C5 antibody has been validated for WB and IHC. It is suitable to detect C5 in samples from Human.

Quick Overview for C5 antibody (AA 1223-1421) (ABIN1885991)

Target: C5 (Complement Component 5 (C5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C5 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-C5 Antibody

Binding Specificity: AA 1223-1421

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1223 and 1421 of Human C5

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.50-1.500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for C5

Target: C5 (Complement Component 5 (C5))

Background: The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes.This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge.An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase.The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections.Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.[provided by RefSeq]

Molecular Weight: 188 kDa

Gene ID: 727

NCBI Accession: NM_001735, NP_001726

Pathways: Complement System, Carbohydrate Homeostasis