GLE1 antibody (AA 414-656)

Catalog No. ABIN1886454

Product Details anti-GLE1 Antibody

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Binding Specificity: AA 414-656

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 414 and 656 of GLE1

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for GLE1

Target: GLE1 (GLE1 RNA Export Mediator (GLE1))

Alternative Name: GLE1 (GLE1 Products)

Background: This gene encodes a predicted 75-kDa polypeptide with high sequence and structure homology to yeast Gle1p, which is nuclear protein with a leucine-rich nuclear export sequence essential for poly(A)+RNA export.Inhibition of human GLE1L by microinjection of antibodies against GLE1L in HeLa cells resulted in inhibition of poly(A)+RNA export.Immunoflourescence studies show that GLE1L is localized at the nuclear pore complexes.This localization suggests that GLE1L may act at a terminal step in the export of mature RNA messages to the cytoplasm.Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq]

Molecular Weight: 75 kDa

Gene ID: 2733

NCBI Accession: NM_001499, NP_001490