SAFB antibody (AA 476-705)

Catalog No. ABIN1886502

The Rabbit Polyclonal anti-SAFB antibody (ABIN1886502) specifically detects SAFB in WB and IF. The antibody is reactive with Human samples.

Quick Overview for SAFB antibody (AA 476-705) (ABIN1886502)

Target: SAFB (Scaffold Attachment Factor B (SAFB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SAFB antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Product Details anti-SAFB Antibody

Binding Specificity: AA 476-705

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 476 and 705 of HET/ SAF B

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for SAFB

Target: SAFB (Scaffold Attachment Factor B (SAFB))

Alternative Name: HET/ SAF B

Background: This gene encodes a DNA-binding protein that has highfor scaffold or matrix attachment region DNA elements (S/MAR DNA).This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein.Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR.This encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes.It is involved in the regulation of the heat shock protein 27 transcription and also can act as an estrogen receptor corepressor.This gene is a candidate gene for breast tumorigenesis.[provided by RefSeq]

Molecular Weight: 103 kDa

Gene ID: 6294

NCBI Accession: NM_002967, NP_002958

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway