FGD4 antibody (AA 49-297)

Catalog No. ABIN1886512

This Rabbit Polyclonal antibody specifically detects FGD4 in WB, IF and IHC. It exhibits reactivity toward Human.

Quick Overview for FGD4 antibody (AA 49-297) (ABIN1886512)

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD4 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC)

Product Details anti-FGD4 Antibody

Binding Specificity: AA 49-297

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 49 and 297 of FGD4

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.500
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 M Tris-buffered saline with 10 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for FGD4

Target: FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))

Alternative Name: FGD4

Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape.This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes.This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP.The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract.Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system.[provided by RefSeq]

Molecular Weight: 87 kDa

Gene ID: 121512

NCBI Accession: NM_139241, NP_640334

Pathways: Neurotrophin Signaling Pathway