POLG antibody (AA 779-1191)

Catalog No. ABIN1886660

The Rabbit Polyclonal anti-POLG antibody has been validated for WB, IHC and IF. It is suitable to detect POLG in samples from Human.

Quick Overview for POLG antibody (AA 779-1191) (ABIN1886660)

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This POLG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-POLG Antibody

Binding Specificity: AA 779-1191

Purification: Purified by antigen-affinity chromatography.

Immunogen: Recombinant protein fragment contain a sequence corresponding to a region within amino acids 779 and 1191 (P54098) of DNA polymerase gamma

Application Details

Application Notes: Suggested dilutions:
Western blotting: 1.500-1.3000
Immunohistochemistry: 1.100-1.250
Immunofluorescence: 1.100-1.200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 1 x PBS, 1 % BSA, 20 % Glycerol (pH 7.0).0.01 % Thimerosal was added as a preservative.

Preservative: Thimerosal (Merthiolate)

Precaution of Use: Biohazard Informations: This product contains thimerosal which is hazardous.

Storage: 4 °C/-20 °C

Storage Comment: Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.

Target Details for POLG

Target: POLG (Polymerase (DNA Directed), gamma (POLG))

Alternative Name: DNA Polymerase gamma

Background: Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit.The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase.The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic.Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE).Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq]

Molecular Weight: 140 kDa

Gene ID: 5428

NCBI Accession: NM_002693, NP_002684